Endocrine Abstracts

Patients affected by adult growth hormone deficiency (aGHD) show worse metabolic profile, with insulin-resistance, increased total cholesterol, LDL, triglycerides, reduced HDL, and higher risk of developing type 2 diabetes mellitus and cardiovascular complications. Adult GHD and metabolic syndrome (MetS) are closely related to each other, since they share the previous depicted clinical features, while obese MetS patients display lower IGF-1 levels due to a functional reduction...

Adult growth hormone deficiency (GHD), a condition characterized by increased oxidative stress (OS), is related to augmented cardiovascular, metabolic and oncological risk. Thymidine-glycol (ThyG) (5, 6-dihydro-5, 6-dihydroxy-2’-deoxythymidine) is a marker of DNA oxidation produced when thymidine is damaged by hydroxyl radicals. It is considered a specific marker since it is not incorporated in RNA; while 8-OH-deoxyguanosine, a well-known marker of oxidative damage, is ra...